Prediction of term and preterm parturition and treatment monitoring by measurement of cervical cross-linked collagen using light-induced fluorescence.

One of the keys to treating preterm labor is the early detection of changes indicating the onset of parturition. Recently, we have developed a non-invasive method for the objective evaluation of the status of the cervix, where changes in collagen content of the cervix can be detected using an optical system and light-induced autofluorescence (LIF). This system measures the collagen fluorescence in the cervix as an indirect estimate of collagen concentration. Studies of pregnant women during the past few years support the use of this technique.